In "The Best of Both Worlds," 40 Starfleet starships gather near Wolf 359 to intercept a Borg cube ship traveling to Earth.^[1] The Borg, having assimilated Captain Jean-Luc Picard (Patrick Stewart) and his knowledge of Starfleet tactics and technology into its collective consciousness, obliterate the Starfleet force: according to dialog in "The Drumhead," 39 ships are destroyed, with the loss of over 11,000 lives.^[1] Survivors include Benjamin Sisko (Avery Brooks) and his son, Jake (Cirroc Lofton),^[1] as well as an unknown number of Starfleet and Klingon captives assimilated by the Borg.^[2] Following its victory, the Borg ship continues on its course to Earth, where the crew of the Enterprise-D rescue Picard and stop the cube.^[1]

The player's character in the interactive movie/video game Star Trek: Borg replaces a crewman aboard the character's father's ship during the events leading to the Battle of Wolf 359, and to change history to prevent the ship from being destroyed there.^[3]